Mathematical Model of a Bacteria-Immunity System with the Influence of Quorum Sensing Signal Molecule
نویسندگان
چکیده
A recent study illustrates an exciting new element of bacteria-host interactions in which the opportunistic pathogen Pseudomonas aeruginosa quorum sensing signal molecule can modulate the host immune system. In this paper, on the basic of a model which describes the competition between bacteria and immune system, a mathematical model is proposed to investigate the modulation of quorum sensing signal molecule on immune response. It is shown that the modulation leads to a backward bifurcation and some more new dynamical behaviors. By numerical simulations, we find a fold bifurcation of equilibria, which induces three patterns of dynamical behaviors including the bistable phenomenon. Our model quantifies the modulation of quorum sensing signal molecule on the immune response, which may provide a therapy for bacteria infections.
منابع مشابه
Quorum Sensing in Microbial Virulence
Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by microorganisms to elicit expression of target genes in response to environmental stimuli or need of microbial communities. Type I system acts by using acyl homoserine lactones as signals to trigger the ex...
متن کاملAnalysis of a periodic bacteria-immunity model with delayed quorum sensing
Based on [J. Zhang, M. Cerasuolo, P. Fergola, Z.E. Ma, On the influence of quorum sensing in the competition between bacteria and immune system (in press)], a bacteriaimmunitymodelwith periodically bacterial quorum sensing is formulatedwhich describes the competition between bacteria and immune cells. A discrete delay is introduced to characterize the time in which bacteria receive signal molec...
متن کاملModeling Quorum Sensing in Sinorhizobium meliloti
Background: For bacteria, it is important for survival to sense their population density or quorum. We use a well-known quorum sensing system of the nitrogen-fixing bacterium Sinorhizobium meliloti in order to study and model its molecular basis. The quorum sensing system depends upon the players ExpR, SinR, SinI and AHL, the signaling molecule within the system. Results: We present a minimal m...
متن کاملINHIBITORY EFFECT OF STEVIA AND ROSA EXTRACTS AGAINST BACTERIAL QUORUM SENSING
Background & Aims: Quorum Sensing is a mechanism by which orchestrate the expression of many genes in bacteria. Therefore, any interference with the system will inhibit bacterial infections. The principal purpose of the research was to evaluate the potential of anti-quorum sensing of Rosa damascena and Stevia rebaudiana against Staphylococcus aureus. Materials & Methods: Ten isolates of Staphy...
متن کاملEffector-stimulated single molecule protein-DNA interactions of a quorum-sensing system in Sinorhizobium meliloti.
Intercellular communication by means of small signal molecules coordinates gene expression among bacteria. This population density-dependent regulation is known as quorum sensing. The symbiotic nitrogen-fixing bacterium Sinorhizobium meliloti Rm1021 possesses the Sin quorum sensing system based on N-acyl homoserine lactones (AHL) as signal molecules. Here, we demonstrate that the LuxR-type regu...
متن کامل